What makes this show truly unique is the relationship between all of the characters and how they grow together, especially the friendship between Detective Jane Rizzoli and Doctor Maura Isles. Their natural chemistry gives the series most of its humor. Jane, the tough tomboy, and Maura, the quirky fashionista, constantly but heads during every episode. Although, the differences between the two of them are what makes their friendship irreplaceable.
In the gif below is just one of the many funny moments in Rizzoli and Isles. Jane tells Maura to listen to her gut, but the analytic medical examiner tells her that she "does not listen to her intestines." This was one of my favorite episodes back in season 2:
In this gif, Jane goes to eat a cupcake when Maura walks in on her and scolds her for eating unhealthy. This happens in just about every episode of the show:
After solving a case: